Autism – A Neurodevelopmental Journey from Genes to by Valsamma Eapen

By Valsamma Eapen

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Nordahl, C. W. (2010). Bridging the Gap between MRI and Postmortem Research in Autism. Brain research, 1380, 175-186. Schwartz, E. , Cooper, E. , Jawad, A. , & Hackney, D. B. (2005). MRI diffusion coefficients in spinal cord correlate with axon morphometry. NeuroReport, 16(1), 73-76. , Kabani, N. , Lerch, J. , Evans, A. (2008). Neurodevelopmental trajectories of the human cerebral cortex. The Journal of neuroscience, 28(14), 3586-94. Shenton, M. , Dickey, C. , & McCarley, R. W. (2001). A review of MRI findings in schizophrenia.

Moreover, recent studies, performed on both animal models and postmortem human samples, suggest that GABAergic neurons and circuits may be altered in ASD. It is likely that the imbalance between excitation and inhibition resulting from neurodevelopmental defects in GABAergic circuitry might represent a common cause for ASD and epilepsy. Here, we will review the genetic, cellular, anatomical and neurophysiological studies that support this hypothesis. 26 Autism – A Neurodevelopmental Journey from Genes to Behaviour 2.

Leyden, K. , & Shukla, D. K. (2011). Underconnected, but How? A Survey of Functional Connectivity MRI Studies in Autism Spectrum Disorders. Cerebral cortex. Neil, J. , Shiran, S. , McKinstry, R C, Schefft, G. , Snyder, A. , Aronovitz, J. , Miller, J. , & Lee, B. , & Conturo, T. E. (1998). Normal brain in human newborns: apparent diffusion coefficient and diffusion anisotropy measured by using diffusion tensor MR imaging. Radiology, 209(1), 57-66. , & Hüppi, P S. (2002). Diffusion tensor imaging of normal and injured developing human brain - a technical review.

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