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Variable domain exon sequences are human while the genetic machinery that drives antibody expression, including extensively optimized promoters and enhancers, is of mouse origin. This Mouse offers biologic drug researchers a facile solution for isolation of exceptional therapeutic antibody candidates. Whatever we thought we knew about something we discovered in the pitcher plant, it’s never quite what it seems. com. ©TRIANNI, Inc 012017 ficial stomachs, and healthy human subjects (Aliment Pharmacol Ther, 42:27385, 2015).
A DEMETER-like DNA demethylase governs tomato fruit ripening,” PNAS, 112:10804-09, 2015. 11. C. , “Reprogramming of DNA methylation is critical for nodule development in Medicago truncatula,” Nat Plants, 2:16166, 2016. 12. M. , “Loss of Karma transposon methylation underlies the mantled somaclonal variant of oil palm,” Nature, 525:53337, 2015. Vegetative cell Pollen tube Sperm combine with the diploid central cell and egg to form the triploid endosperm and the diploid embryo, respectively. VEGETATIVE NUCLEUS CG LOSS IN VEGETATIVE CELL The nonreproductive nucleus loses some CG methylation and many transposons are activated as a result.
That was my eureka moment,” Banks says. She wrote to coauthor Scott McAdam right away to tell him about her mutants— which she reasoned could provide genetic evidence that McAdam and his advisor Tim Brodribb were right about ABA signaling in ferns. Upon receiving some of Banks’s mutants, McAdam began experimenting with the plants to confirm that they indeed had normal responses to humidity despite being insensitive to ABA. “The ferns had very predictable responses, exactly what we’d expect [of wild-type plants],” he says.