By Paul Imbach (auth.), Paul Imbach, Thomas Kühne, Robert J. Arceci (eds.)
This can be the second one version of a well-received compendium of knowledge and suggestions at the prognosis and administration of a number of the oncological ailments which are encountered in kids and teenagers. for every disorder entity, primary proof are only if could be correct for various pros – medical institution physicians, expert nurses, psycho-oncologists, physiotherapists, relatives medical professionals, and pediatricians. in comparison with the 1st version all chapters were up to date. all through, speedy orientation is ensured by means of the transparent, constant format and the concise, lucid kind. Pediatric Oncology: A complete advisor is a superb, easy-to-use reference that belongs at the shelf of each practitioner who encounters or treats malignancies within the pediatric age team. Pediatric Oncology is teamwork! basic proof for all these serious about analysis and administration – even social employee, pedagogic lecturers, spiritual care individuals
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3 Allogeneic Hematopoietic Stem Cell Transplantation.......................................... 4 Autologous Hematopoietic Stem Cell Transplantation........................................ 7 Characteristics of and Therapy for AML Subtypes.......................................................... 1 Acute Promyelocytic Leukemia (APL, M3)......................................................... 2 Acute Myelomonocytic and Acute Monocytic Leukemia (M4, M5)................... 3 Erythroleukemia (Di Guglielmo Syndrome, M6).................................................
1, page 9). 3 Allogeneic Hematopoietic Stem Cell Transplantation • The possibility of an antileukemic effect of the donor immune system (graft vs leukemia or GVL), together with supportive therapy and prophylaxis against graft-versus-host disease (GVHD), results in an improved outcome for certain subtypes of AML (see discussion above) • A GVL effect is less effective in transplantation between identical twins or after extensive T-cell depletion of the donor stem cells • Adverse late sequelae after transplantation include chronic GVHD, growth retardation, sterility, and the risk of secondary malignancy • The frequency of leukemia-free survival after transplantation is 50–70% In the absence of an HLA matched, family donor, matched or mismatched unrelated bone marrow or cord blood donors may be used; in some instances, related haploidentical donor transplantation may be considered.
2 Leukostasis • If WBC is higher than 200 × 109/l, leukemic blasts may clump intravascularly. 3 Tumor Lysis Syndrome See Chap. 18. 6 Therapy • Before 1970, nearly all children with AML died. Since then cooperative study protocols with different cytotoxic drug combinations have led to long-term remission in approximately 50–60% of children (see also table Prognostic factors in AML) • Allogeneic hematopoietic stem cell transplantation (HSCT) has been reported in multiple studies to improve disease-free survival but not always overall survival because of treatment-related mortality.