Nature (Vol. 436, No. 7052, 11 August 2005)

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We generated 370 Mb of finished sequence, representing 95% coverage of the genome and virtually all of the euchromatic regions. 9 kb in rice. A total of 2,859 genes seem to be unique to rice and the other cereals, some of which might differentiate monocot and dicot lineages. Gene knockouts are useful tools for determining gene function and relating genes to phenotypes. We identified 11,487 Tos17 retrotransposon insertion sites, of which 3,243 are in genes. 43% of the nuclear genome contains organellar DNA fragments, representing repeated and ongoing transfer of organellar DNA to the nuclear genome.

Et al. Nature 412, 635–638 (2001). 9. Carpenter, E. J. Mar. Ecol. Prog. Ser. 188, 273–283 (1999). 10. Codispoti, L. A. et al. Sci. Mar. 65, 85–105 (2001). haematopoietic stem cells (HSC), that had been manipulated to express either normal (wild-type) or mutated MYC, and then followed the formation of tumours. When HSC expressing wild-type MYC were used, lymphomas developed in a small fraction of the mice only after a long period. By contrast, most of the mice grafted with HSC carrying mutant MYC quickly developed tumours, indicating that the MYC mutants are far more tumorigenic than wild-type MYC.

Abo, A. & Ridley, A. J. J. Cell Sci. 115, 3947–3956 (2002). 9. Wang, T. L. et al. Proc. Natl Acad. Sci. USA 99, 16156–16161 (2002). 10. Samuels, Y. et al. Science 304, 554 (2004). Supplementary information accompanies this communication on Nature’s website. Competing financial interests: declared online. 1038/nature03895 ARTICLES The map-based sequence of the rice genome International Rice Genome Sequencing Project* Rice, one of the world’s most important food plants, has important syntenic relationships with the other cereal species and is a model plant for the grasses.

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