By Dieter Häussinger, Editor
Realizing the mechanisms concerned about liver regeneration is of an important value for medical drugs, not just concerning carcinogenesis and diabetes remedy, but additionally for using stem cells for phone treatment and liver surgical procedure. This graduate-level textual content presents an outline of the present nation of information of the molecular mechanisms of liver regeneration. Hepatic stem cells are brought and the real avid gamers keen on regeneration equivalent to oval cells, bone marrow and stellate cells are reviewed. The phone signaling pathways that begin liver regeneration and keep an eye on the swap among proliferation and apoptosis are awarded and the position of liver stem cells in tumorigenesis is mentioned. The ebook additionally treats the epigenetic rules of liver stem cells and the jobs of irritation and angiogenesis in liver regeneration. This compact evaluation of the attention-grabbing regenerative means of the liver might be of curiosity to graduate scholars and post-docs in molecular biology, biochemistry and drugs.
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Extra info for Liver Regeneration (De Gruyter Textbook)
Sample text
Surg. 169, 126–32. , Magnuson, M. et al. (2005). Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy. Oncogene 24, 3028–41. E. (1998). Liver regeneration is transiently impaired in urokinase-deficient mice. Am. J. Physiol. 275, G1472–9. , Kawata, S. et al. (2002). NF-kappaB activation in non-parenchymal liver cells after partial hepatectomy in rats: possible involvement in expression of heparinbinding epidermal growth factor-like growth factor.
Physiol. 275, G1472–9. , Kawata, S. et al. (2002). NF-kappaB activation in non-parenchymal liver cells after partial hepatectomy in rats: possible involvement in expression of heparinbinding epidermal growth factor-like growth factor. J. Hepatol. 36, 527–33. , and Birchmeier, C. (1995). Scatter factor/hepatocyte growth factor is essential for liver development. Nature 373, 699–702. W. (2001). Shear stress-induced nitric oxide release triggers the liver regeneration cascade. Nitric Oxide 5, 453–64.
Clin. Invest. 91, 1319–26. , and Todo, S. (2009). The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositidedependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation. Hepatology 49, 204–14. , and Anderson, R. (1931). Experimental pathology of the liver. I. Restoration of the liver in the white rat following partial surgical removal. Arch. Pathol. 12, 186–202. , and Bosca, L. (2007). Animal models for the study of liver regeneration: role of nitric oxide and prostaglandins.