By Архангельская В. М.
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This explains why numerous and extensive investigations have 38 V. Labet et al. been devoted to the characterization, measurement, and biological assessment (repair, mutagenic potential) of DNA lesions. More recently, major efforts have been made to complement the above information by using theoretical approaches for gaining further insights into the chemical reactivity of the bases. In the present chapter, emphasis is placed on the critical review of information gained from the use of density functional theory-based descriptors that shed new light on the endogenous and exogenous formation of several single and tandem lesions.
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