By Beilstein F.
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Indd 25 8/21/2013 4:14:39 PM b1569 Selected Topics in Nanomedicine 26 Selected Topics in Nanomedicine Multienzymes in AC (Gu & Chang 1988) Convert urea & ammonia to amino acids NH3 urea NH 3 a-ketoisocaproate a-ketoisovalerate DL-a-keto-ß-methyl -n-valerate urease urea L-leucine L-valine L-isoleucine LEUDH Dextran-NAD Dextran-NADH + GDH D-glucose D-glucono-lactone A COMPLETE NANO-ARTIFICIAL RBC (80 nm diameter ) Chang (2005) Nature Review: Drug Discovery Chang (2010) WIRE Nanomedicine & Nanobiotechbology GLUCOSE GLUCOSE Biodegradable polymeric Membrane ADENINE, INOSINE ATP EMBDEN-MEYERHOF SYSTEM HEMOGLOBIN O2 NAD 2,3-DPG NADH METHB REDUCING AGENT Ascorbic acid LACTATE LACTATE CARBONCIC ANHYDREASE SUPEROXIDE DISMUTASE CATALASE CO 2 SUPEROXIDE H2O2 Fig.
Journal of Pharmacology and Experimental Therapeutics 325(2): 400–408. Gazzard BG, Portmann BA, Weston MJ, et al. (1974) Charcoal haemoperfusion in the treatment of fulminant hepatic failure. Lancet 1: 1301–1307. Gould SA, et al. (2002) The life-sustaining capacity of human polymerized hemoglobin when red cells might be unavailable. J Am Coll Surg 195: 445–452. Gregoriadis G (ed). (1976) Drug Carriers in Biology and Medicine. , New York. Greenburg AG, Pitman A, Pearce LB, Kim HW. (2008) Clinical contextualization and the assessment of adverse events in HBOC trials.
This way, external magnetic fields can direct their movement; remove or separate them from a mixture; retain them at specific site of action; stir or agitate them as in bioreactors, and other possibilities. g. in bioreactors) (5) etc Extracellular Fig. 26. Artificial cells containing biologics can also contain magnetic material. indd 31 8/21/2013 4:14:42 PM b1569 Selected Topics in Nanomedicine 32 Selected Topics in Nanomedicine at site of tumor and other areas of application. , 2013). 7. , 1966) (Fig.