By Karolin K. Kroening
This e-book describes nerve brokers and vesicants, their decomposition and their degradation items' chemistry in addition to their toxicity together with a listing of detection suggestions of nerve brokers and their degradation items. This booklet will current their heritage, toxicity, comparability among various pattern coaching equipment, separation strategies, and detection tools all jointly in a quick, effortless to learn booklet, tied jointly through a unmarried workforce doing the writing and the modifying to guarantee gentle transition from bankruptcy to bankruptcy, with adequate Tables and literature references for the reader who appears to extra detail.The textual content will illustrate the pluses and minuses of many of the strategies with enough references for the reader to procure wide aspect.
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Extra resources for Analysis of Chemical Warfare Degradation Products
4 Acute exposure data for GB degradation products and impurities. Table taken from Reference  with permission from Environmental Health Perspectives 30 ANALYSIS OF CHEMICAL WARFARE DEGRADATION PRODUCTS – – Rat: inhalation, 75 ppm per 4 h  Mouse: intravenous, 36 mg kg−1  Rat: oral, 740 mg kg−1  Rat: oral, 540 mg kg−1  Mouse: oral, 114 mg kg−1  Rabbit: oral, 615 mg kg−1  Guinea pig: oral, 350 mg kg−1  Rabbit: skin, 250 μL kg−1 (194 mg kg−1 )  Diisopropyl carbodiimide (DIPC) Tributylamine (TBA) 4a Methylphosphonic Mouse, dog: inhalation, 2700 mg m−3 per 30 min  difluoride Rat: inhalation, 8100 mg m−3 per 30 min  Monkey: inhalation, 3000 mg m−3 per 30 min  Guinea pig: inhalation, <1600 μg L−1 per 1 h (mg m−3 )  Human: central nervous system stimulation, skin irritation, sensitization [56, 57] Human: eye, skin, and respiratory irritant  Rat, mouse, dog, monkey: eye irritation  Rat, dog, monkey: corneal opacity, haze  Mouse: muscle weakness, ataxia  Dog, monkey: miosis  Rat, mouse, guinea pig: respiratory distress [44, 51] Dog: pulmonary edema, congestion  – TOXICITY OF DEGRADATION PRODUCTS 31 – – Diisopropyl methylphosphonic acid (DIMP) Carcinogenicity Isopropyl methylphosphonic acid (IMPA) Compound Mutagenicity: Salmonella, negative  Mutagenicity: S.
Willison and Joseph A. Caruso. © 2011 John Wiley & Sons, Ltd. Published 2011 by John Wiley & Sons, Ltd. 1 ORGANOPHOSPHORUS NERVE AGENT TOXICITY The toxicity of organophosphorus nerve agents has been well documented [1–3]. Following the discovery of the synthetic procedure in the 1850s, the Germans were the first to produce organophosphorus nerve agents on a large scale, in the late 1930s . Considered the most toxic of all chemical warfare agents (CWAs), the first reported use of organophosphorus nerve agents [Tabun (GA) and Sarin (GB)] was by Iraq against Iran during the first Gulf War and also against Kurdish rebels .
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