By Diane Watters, Martin Lavin
Apoptosis, or programmed phone demise, is an important approach in which a mobile may well die with no adversely affecting its surroundings. It performs a very important function in basic improvement, and within the body's defence mechanisms opposed to illness. an excessive amount of mobilephone demise is harmful, resulting in neurodegenerative illnesses and impaired improvement. Conversely, too little mobilephone demise may end up in an elevated susceptibility to melanoma and sustained viral an infection. Apoptosis is an issue of balanceDramatic development has been made within the examine of apoptosis over the last decade. essentially the most swiftly increasing wisdom bases being proven is at the molecular mechanisms managed by way of numerous gene items together with Bcl-2, caspases, demise receptors, and proteolytic pursuits, in addition to the significant function of the mitochondrion. the most important problem in apoptosis study is how the protein items concerned function in an tricky internet of signaling pathways that still play an important position in mobile proliferation and differentiation. This ebook concentrates on elucidating those sign transduction mechanisms, a space now not accurately reviewed through different apoptosis texts.
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Extra resources for Signalling Pathways in Apoptosis (Modern Genetics, Vol. 5)
Example text
Kimchi, A. and Oren, M. (1991) Wildtype p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature, 352, 345–347. M. R. (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β converting enzyme. Cell, 75, 641–652. , Sato, T. C. (1996) Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2. J. Biol. , 21, 7440–7444. , Jockel, J. J. (1996) Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14–3–3 not BCL-XL.
Nature, 374, 731–733. , et al. , 14, 1914–1922. , et al. (1996) In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc. Natl. Acad. , 93, 7464–7469. , Litwack, G. S. (1995) Mch2, a new member of the apoptotic Ced-3/ICE cysteine protease gene family. , 55, 2737–2742. , Litwack, G. and Alnemri, E. (1994) CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1β-converting enzyme.
1995) Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K. Nature, 374, 731–733. , et al. , 14, 1914–1922. , et al. (1996) In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc. Natl. Acad. , 93, 7464–7469. , Litwack, G. S. (1995) Mch2, a new member of the apoptotic Ced-3/ICE cysteine protease gene family. , 55, 2737–2742. , Litwack, G. and Alnemri, E. (1994) CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1β-converting enzyme.