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The concentration of the tumor marker should reflect the size of the tumor. 5. The testing method should be affordable to facilitate screening of many people. Tumor markers are measured qualitatively or quantitatively by chemical, immunologic, or molecular biologic methods. Several confounding factors limit the applicability of certain tumor markers. The sensitivity of a particular tumor marker depends on the assay’s ability to detect the marker, the tumor size needed to produce a detectable amount of tumor marker, and the percentage of tumor marker expression for the specific tumor.
If the sentinel lymph node is histologically negative, then the other lymph nodes in the basin are also histologically negative. Sentinel Lymph Node Biopsy for Melanoma The presence or absence of lymph node metastases is the single most powerful predictor of recurrence and survival for melanoma patients. 0 mm thick should undergo a nodal staging procedure so that adjuvant therapy can be selectively administered. Given the substantial difference in disease-free and overall survival, it is important to offer these patients interferon alfa-2β therapy.
A tumor marker must have several characteristics to be ideal for clinical use. 1. The molecule must be detectable before neoplastic spread begins. 2. The marker must be sensitive (it should be detectable in all patients who have the neoplasm). 3. The marker must be specific (a positive test for the marker should not occur in patients without the neoplasm). 4. The concentration of the tumor marker should reflect the size of the tumor. 5. The testing method should be affordable to facilitate screening of many people.