By P. Michael Conn
Receptors begin the skill during which mobile regulators exert their activities on the right track cells. end result of the valuable position of cell-cell conversation and sign transduction, receptors are of intrinsic curiosity to neuroscientists. Receptor reports make the most of either conventional tools of research and smooth molecular ideas. This quantity examines finished protocols for ''model'' receptor concepts (radioligand binding, solubilization and purification). It additionally describes the technique for the subsequent receptors: bombesin/GRP, cholecystokinin, endothelin, speedy nerve development issue and gastrin-releasing peptide, insulin, insulin-like progress components, interleukin 1, melanotropin, melatonin, natriuretic hormone, neurokinin, neurokinin, neurotensin, PACAP, pancreatic polypeptide, serotonin, steroids, transferrin and vasoactive peptides
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Receptors: Model Systems and Specific Receptors
Receptors start up the skill wherein mobile regulators exert their activities on track cells. a result of relevant function of cell-cell conversation and sign transduction, receptors are of intrinsic curiosity to neuroscientists. Receptor experiences make the most of either conventional tools of study and sleek molecular strategies.
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Extra info for Receptors: Model Systems and Specific Receptors
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T h e s e effects are mediated by specific r e c e p t o r s , of which t w o types (AT, and AT2) h a v e b e e n identified by binding studies; only A T , , h o w e v e r , has b e e n s h o w n to be a functional entity by biological in vivo and in vitro assays (42, 43). A. 25 M) 1,047 496 ANP-C-R Rat aorta 56,000-80,000 Adenylcyclase VIP-R Rat liver AT2 24 21 17 Ref. 14 25 Guanylcyclase 23 Adenylcyclase IP3 359 41,093 G protein 13 Bovine adrenal Uterus, adrenal ? ? medulla, brain — — — — — B2 Rat uterus 366 41,696 G protein 15 NK-1 Rat brain 407 46,364 G protein 16 NK-2 Bovine stomach 390 43,851 G protein NK-3 Rat brain 452 51,104 G protein 18 Bovine lung 427 48,500 G protein 19 ETB Rat lung 415 46,900 G protein 20 ANP-Rj Rat brain (nM) 1,057 Guanylcyclase Receptor Tissue Major Features of Receptors for Vasoactive Peptides Endothehn ETA Substance Ρ Bradykinin Angiotensin Peptide TABLE 22 V, 394 Human uterine myometrium Rat kidney Rat liver OT V2 Y2 Human placenta 370 Porcine spinal cord Porcine coronary artery Porcine left atria Human neuroblastoma (MC-IXC) Rat hippocampus Rabbit kidney Rat brain CGRP-R IP3, inositol triphosphate.
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