By Dr. Yury O. Chernoff
This e-book covers a subject that has been ignored for years and has back to the highlight just recently. until eventually the genetic function of DNA was once firmly demonstrated, many researchers suspected that proteins, instead of nucleic acids, might be providers of heritable details. notwithstanding, those versions have been thoroughly forgotten with the triumphal march of the double helix and the improvement of a critical dogma postulating that info circulate happens strictly from DNA, via RNA, to protein, making it possible most unlikely for the proteins to own a coding capability. Proteins have been downgraded to the position of straightforward perpetuators and executors of DNA orders. Taken jointly, facts incorporated during this e-book end up past a cheap doubt that proteins and multiprotein complexes may be able to keep an eye on heritable qualities, and that, at the least in a few examples, this keep watch over happens in a template-like type, in order that new constructions strictly reproduce styles of pre-existing buildings that weren't in particular coded in DNA. therefore, protein-based inheritance has left the world of hypothesis and has emerged as a brand new subject amenable to top quality experimental research.
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Conservation of tandem stop codons in yeasts. Genome Biol 2005; 6:R31. 78. Namy O, Duchateau-Nguyen G, Rousset JP. Translational readthrough of the PDE2 stop codon modulates cAMP levels in Saccharomyces cerevisiae. Mol Microbiol 2002; 43:641-652. 79. Wilson MA, Meaux S, Parker R et al. Genetic interactions between [PSI+] and nonstop mRNA decay affect phenotypic variation. Proc Natl Acad Sci USA 2005; 102:10244-10249. 80. Hattendorf DA, Lindquist SL. Cooperative kinetics of both Hsp104 ATPase domains and interdomain communication revealed by AAA sensor-1 mutants.
Eaglestone S, Ruddock LW, Cox BS et al. Guanidine hydrochloride blocks a critical step in the propagation of the prion-like determinant [PSI+] of Saccharomyces cerevisiae. Proc Natl Acad Sci USA 2000; 97:240-244. 65. Ferreira PC, Ness F, Edwards SR at al. The elimination of the yeast [PSI+] prion by guanidine hydrochloride is the result of Hsp104 inactivation. Mol Microbiol 2001; 40:1357-1369. 66. Jung GM, Jones G, Masison DC. Amino acid residue 184 of yeast Hsp104 chaperone is critical for prion-curing by guanidine, prion propagation, and thermotolerance.
PSI+] Is the Prion form of Sup35p In addition to proposing that the non-Mendelian inheritance of the phenotypically unrelated [URE3] determinant could be explained by the prion-like behaviour of the Ure2 protein (Ure2p), Wickner6 also suggested that the [PSI +] determinant might be due to a prion. , Cox’s mysterious ψ factor) is the prion form of Sup35p23-25 (recent reviews). 26,27 With the recognition that [PSI +] is the prion form of Sup35p, many if not all of the unusual genetic properties that Cox described for the ψ factor could be accounted for: non-Mendelian inheritance, dependency on a nuclear gene, cytoduction and failure to associate with a known cytoplasmic nucleic acid genome (Fig.