By Nima Mowzoon, Kelly D. Flemming
Collect the data of examination takers and citizens with the one up to date one-stop illustrated evaluate for the written component of the Neurology Board and in-service examinations.
Valuable contributions via examination takers and citizens make this the best assets for examination practise or smooth daily resident training—here are only a couple of merits…
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Structural proteins of neurons. TM, transmembrane. 4) Actin-binding proteins determine structural arrangement of actin microfilaments and cross-linking and interactions with cell membrane and extracellular matrix a) Spectrin: acts to cross-link actin oligomers and forms complex with ankyrin, actin, and other cytoskeletal proteins, forming stable submembranous cytoskeletal complex, stabilizing cell membranes b) Ankyrin c) Fibrin: may be important in formation of filopodia in growth cones d) Profilin: promotes actin polymerization e) Gelsolin: cytoplasmic, calcium-regulated, actinmodulating protein that binds to and severs existing actin filaments and can cap F-actin; mutations of gelsolin lead to familial amyloidosis type IV, Finnish type b.
Answer: d. Anencephaly is the disorder of neurulation associated with failure of closure of the anterior neuropore and defective notochord induction of the neuroectoderm. Midline malformations are due to either abnormal lateral growth of the cerebral hemispheres because of abnormal migration or abnormal differentiation of the telencephalon from the lamina terminalis, which is formed by closure of the anterior neuropore. BASIC PRINCIPLES OF NEUROSCIENCE AND NEUROGENETICS 2 Orhun H. D. Gena R. D.
Broadening of gyri diffusely d. Primary causes 1) Isolated familial megalencephaly (autosomal dominant or recessive) 2) Isolated sporadic megalencephaly 3) Associated with endocrine disorders, agenesis of corpus callosum, and achondroplasia e. Secondary causes 1) Inborn errors of metabolism: GM1 and GM2 gangliosidoses, mucopolysaccharidoses, leukodystrophies such as Alexander disease and Canavan disease 2) Neurocutaneous disorders such as neurofibro- 18 Chapter 1 Embryology and Developmental Disorders of the Nervous System matosis 1, tuberous sclerosis, linear sebaceous nevus syndrome 2.