By Brody H., et al. (eds.)
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Extra resources for Nature outlook: Nutrigenomics. How food shapes health and evolution
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The final sample consisted of 454 individuals. All procedures were in accordance with good clinical practice. Written consent was obtained from each patient before participation and the study principles were approved by the Research Ethics Committee of the Virgen de la Arrixaca Hospital. Patient data were codified to guarantee anonymity. 13,14 Briefly, during the initial 4 months, subjects attended a weekly 60-min therapy session in support groups (n ¼ 10), followed by a 5-month maintenance period.
Although specific binding sites are not elucidated in the analysis presented here, the difference in the predicted allele-specific structures is consistent with the hypothesis that this SNP strongly affects mRNA structure and stability. On the other hand, this SNP is in complete LD with rs4864548 (Figure 1), which is located in the promoter region. Variation in the promoter activity may also explain the results we observed. 28 The precise mechanisms linking MetS to circadian system disruption are not well known.
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