By J.M.C. Connell, A.F. Dominiczak, F Soubrier
Molecular Genetics of high blood pressure is without doubt one of the first books to consolidate the present wisdom of this increasing study zone. The e-book considers the learn and purposes of molecular genetic ways to this crucial illness, delivering a comprehMolecular Genetics of high blood pressure is without doubt one of the first books to consolidate the present wisdom of this increasing examine sector.
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Er aL (1995) Genetic decreases in atrial natriuretic peptide and saltsensitive hypertension. Science 267: 679-681. , Schork, N. and Spielberger, C. J. PsychosomaticRes. 31: 731-741. E. and Stanley, D. Dis. 36: 507-516. (1997) Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10. Hum. Mol. 6: 2077-2085. Julius, S. (1995) The defense reaction: a common denominator of coronary risk and blood pressure in neurogenic hypertension?
These data demonstratedthatthe genetic background of the normotensive straindetermines how many genesare segregating with highblood pressure in a given cross. Obviously,the selection of a cross markedly influences the number of loci for a distinct phenotype, and, therefore, limits the identification of the genes responsible for traits suchas high blood pressure. Genetic analysisin its simplest form is assigning a component of the phenotypic variance, in our case blood pressure, tothe three possible genotypes: homozygous for allele1, heterozygous and homozygous for allele2 (in an F, intercross of inbred strains).
Consequently,although investigators have found many differences between the hypertensive strains and the ‘control’ strains they have madelittle headway in defining the initial cause of high blood pressure. Genetic analyses provide means to distinguish primary factors causing hypertension in inbred strains (isogenic) of the rat. Genes playing a role in causing the trait will cosegregate (be linked) with the trait in a cross; whereas, the genes responsible for secondary responses or unrelated strain differences willnot.