By Leonard J. Rosenthal, Hans Wilhelm Doerr
Nearly 15 in keeping with cent of human melanoma prevalence will be attributed to virus an infection, i.e. viruses symbolize the second one most crucial threat issue (after tobacco intake) for melanoma improvement in people. this present day, 5 virus forms are identified to be serious about inflicting human melanoma: papillomaviruses, retroviruses, herpesviruses, hepadnaviruses, and flaviviruses. This quantity of "Monographs in Virology" offers a entire evaluation of a couple of DNA tumor viruses. major specialists within the box of tumor virology talk about up to date details, targeting the remodeling genes of DNA tumor viruses, the mechanisms of transformation and the in vitro technique used for his or her identity and characterization. even supposing DNA tumor viruses are a various workforce, in vitro reviews have printed a number of universal mechanisms of viral transformation. the person chapters of the publication describe the most recent learn at the id of viral oncogenes and their pursuits.
Read Online or Download Mechanisms of DNA tumor virus transformation PDF
Similar genetics books
The influence of molecular genetics on plant breeding and, therefore, agri tradition, is very likely enonnous. knowing and directing this power im pact is essential as a result of pressing matters that we are facing referring to sustainable agriculture for a becoming international inhabitants in addition to conservation of the world's quickly dwindling plant genetic assets.
A job for nutrition A in residing organisms has been identified all through human background. within the final a hundred years, the biochemical nature of diet A and its energetic by-product, retinoic acid, its physiological influence on progress tactics and the basic info of its mechanism of motion were published through investigations performed through researchers utilizing vertebrate and extra lately invertebrate versions to review a multiplicity of techniques and prerequisites, encompassing embryogenesis, postnatal improvement to previous age.
- Microsatellites: Methods and Protocols
- Theoretical atomic spectroscopy
- Genetics of Auditory Disorders, 1st Edition
- Genomic and Personalized Medicine, Second Edition: V1-2
- When Worlds Collide (The Torn Timeline) (Volume 2)
Additional resources for Mechanisms of DNA tumor virus transformation
Proc Natl Acad Sci USA 1986;83:8288–8292. Tornatore 24 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 Trapp BD, Small JA, Pulley M, Khoury G, Scangos GA: Dysmyelination in transgenic mice containing JC virus early region. Ann Neurol 1988;23:38–48. Beggs AH, Miner JH, Scangos GA: Cell type-specific expression of JC virus T antigen in primary and established cell lines from transgenic mice. J Gen Virol 1990;71:151–164. Feigenbaum L, Hinrichs SH, Jay G: JC virus and simian virus 40 enhancers and transforming proteins: Role in determining tissue specificity and pathogenicity in transgenic mice.
Our laboratory constructed a modified PDGF-R that fails to traffic to the cell surface, and thus cannot be activated by the PDGF-R ligand (PDGF BB [27, and unpubl. data]). Despite this apparent defect, this receptor cooperates with E5 to induce cellular transformation of mouse fibroblasts and IL-3-independent growth of 32D cells [D. Clarke and D. Goldstein, unpubl. data]. Reagents such as BPV-1 E5 and this modified receptor should be useful for further elucidating the downstream effects of activating receptors located within intracellular compartments, and determining whether this differs from activating receptors stationed at the cell surface.
However, several studies suggested that alternative mechanisms might exist, such as E5 perturbation of V-ATPase activity. For example, BPV E5 is capable of transforming keratinocytes, which lack PDGF-R . Moreover, several E5 mutants have been shown to either fail to transform cells, despite retaining the ability to induce PDGF-R autophosphorylation, or to retain transforming ability without Goldstein/Sparkowski 38 inducing significant PDGF-R autophosphorylation [22, 35]. Alterations of Golgi pH may thus provide an alternative mechanism to account for cell transformation in situations where E5 ability to activate the PDGF-R is compromised or in cells lacking this receptor.