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Darras, B. , M. Koenig, L. M. Kunkel and U. Francke (1988) 'Direct method for prenatal diagnosis and carrier detection in Duchenne/Becker muscular dystrophy using the entire dystrophin eDNA', American Journal of Medical Genetics, vol. 29, pp. 713--26. de Dunnen, J. , E. Bakker, E. G. Klein Breteler, P. L. Pearson and G. J. B. van Ommen (1987) 'Direct detection of more than 50% of the Duchenne muscular dystrophy mutations by field inversion gels', Nature, vol. 329, pp. 640-2. Forrest, S. , G. S.
Med. , vol. 25, pp. 660-2. Wetton, J. , R. E. Carter, D. T. Parkin and D.
DNA studies showed that the mother transmitted an allele of D4S10 to the affected child but not an allele of D4S43, so that the breakpoint on the short arm of chromosome 4 lay between these two markers (incidentally helping to order these markers which are near the Huntington's Chorea locus). 4) demonstrated that the D4S43 marker had been translocated from chromosome 4 to the short arm of chromosome 12. , 1987). , 1988; Donnai and Andrews, 1988), pose an interesting dilemma. If these tests are undertaken for the detection of Down's syndrome alone then it may be possible to use gene probes for the detection of trisomy 21, either by analysis of interphase cells using in situ hybridisation, or by Southern blot analysis and dosage studies.