GENES V. by Benjamin. Lewin

By Benjamin. Lewin

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Pharmacogenetics 6(5), 429–439. J. O. (1993) Validation of 4-nitrophenol as an in vitro substrate probe for human liver CYP2E1 using cDNA expression and microsomal kinetic techniques. Biochem. Pharmacol. 46(11), 1975–1981. , Ketterer, B. P. (1995) Enhancement of bacterial mutagenicity of bifunctional alkylating agents by expression of mammalian glutathione S-transferase. Chem. Res. Toxicol. 8(3), 465–472. A. J. (1991) Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype.

1999) Heterologous expression and kinetic characterization of human cytochromes P-450: validation of a pharmaceutical tool for drug metabolism research. Drug Metab. Dispos. October; 27(10), 1117–1122. , Thompson, R. B. (2001) In vitro high throughput screening of compounds for favorable metabolic properties in drug discovery. Comb. Chem. High Throughput Screen. 4(3), 245–263. C. H. (1990) Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of foodderived heterocyclic amine mutagens by human cytochromes P-450.

Guo, Z. P. (1994) Expression of modified human cytochrome P450 2E1 in Escherichia coli, purification, and spectral and catalytic properties. Arch. Biochem. Biophys. 312(1), 59–66. M. P. (1995a) Expression of cytochrome P450 2D6 in Escherichia coli, purification, and spectral and catalytic characterization. Arch. Biochem. Biophys. 319(2), 540–550. D. P. (1995b) Expression of cytochrome P450 3A5 in Escherichia coli: effects of 50 modification, purification, spectral characterization, reconstitution conditions, and catalytic activities.

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